产品名称

醋酸磺胺米隆(Mafenide acetate)

一般描述

Mafenide acetate(醋酸磺胺米隆) is a sulfonamide that inhibits the enzyme carbonic anhydrase.

别 称

4-Aminomethylbenzenesulfonamide acetate salt,4-Homosulfanilamide, Mafenide, Marfanil

纯 度

≥99.0%(HPLC)

CAS NO.

13009-99-9

分子式

C⁹H¹⁴N²O⁴S

分子量

246.28

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥45mg/mL

乙醇

Slightly soluble

水

≥45mg/mL

l  生物学信息

生物活性/药理作用

Mafenide Acetate is the acetate salt form of mafenide, a synthetic sulfonamide analog of para-aminobenzoic acid (PABA) with topical anti-infective activity. Mafenide acetate competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, thereby interferes with normal folic acid metabolism. As a result, de novo synthesis of pyrimidines, which requires folate metabolites, is impeded and subsequently DNA synthesis is affected. Mafenide acetate is bacteriostatic against many gram-negative and gram-positive organisms, including Pseudomonas aeruginosa and certain strains of anaerobes.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov