产品名称

甲基多巴(Methyldopa)

一般描述

Methyldopa(甲基多巴) is a phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity.

别 称

(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid; Aldomet

纯 度

≥99.0%(HPLC)

CAS NO.

555-30-6

分子式

C¹⁰H¹³NO⁴

分子量

211.217

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

Slightly soluble

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Methyldopa is a phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.

l  包装与存储

包 装

1g; 5g

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov