产品名称

双嘧达莫(Dipyridamole)

一般描述

Dipyridamole(双嘧达莫) is a synthetic agent derivative of pyrimido-pyrimidine, with antiplatelet properties.

别 称

2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol; 潘生丁; NSC-515776

纯 度

≥99.0%(HPLC)

CAS NO.

58-32-2

分子式

C²⁴H⁴⁰N⁸O⁴

分子量

504.63

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄色或黄色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥45mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Dipyridamole is a synthetic agent derivative of pyrimido-pyrimidine, with antiplatelet properties. Dipyridamole inhibits adenosine uptake by platelets and endothelial cells, triggering an accumulation of cyclic adenosine monophosphate (cAMP), and inhibiting the   stimulation of platelet aggregation by agents such as platelet activating factor and collagen.

Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.

l  包装与存储

包 装

1g; 5g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov