产品名称

硫普罗宁(Tiopronin)

一般描述

Tiopronin is a preion thiol drug used primarily in the treatment of severe homozygous cystinuria.

别 称

2-(2-sulfanylpropanoylamino)acetic acid;N-(2-Mercaptopropionyl)glycine

纯 度

≥98.0%(HPLC)

CAS NO.

1953-02-2

分子式

C⁵H⁹NO³S

分子量

163.19

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥30mg/mL

乙醇

≥30mg/mL

水

≥30mg/mL

l  生物学信息

生物活性/药理作用

Tiopronin is an acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.

Kidney stones form when the solubility limit is exceeded and urine becomes supersaturated with endogenous cystine. Tiopronin is an active reducing agent which undergoes a thiol-disulfide exchange with cystine to form a water-soluble mixed disulfide complex. Thus, the amount of sparingly soluble cystine is reduced. By reducing urinary cystine concentrations below the solubility limit, tiopronin helps reduce cystine stone formation.

l  包装与存储

包 装

50mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov