产品名称

甲磺酸培氟沙星(Pefloxacin Mesylate)

一般描述

Pefloxacin mesylate is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.

别 称

1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;methanesulfonic acid; Pefloxacine monomethanesulfonate; Pefloxacinium methanesulfonate

纯 度

≥99.0%(HPLC)

CAS NO.

70458-95-6

分子式

C¹⁸H²⁴FN³O⁶S

分子量

429.46

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥10mg/mL

乙醇

Insoluble

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Used in the treatment of chemotherapy-induced neutropenia by enhancing the production of neutrophils. Pegfilgrastim acts on hematopoietic cells by binding to specific cell surface   receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional activation.

Pefloxacin is thought to be broken down into amino acids similarly to endogenous proteins.

Pefloxacin binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Pegfilgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Pegfilgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, pegfilgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov