产品名称

唑来膦酸(Zoledronic Acid)

一般描述

Zoledronic acid is a potent osteoclast inhibitor.

别 称

(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid;Zoledronate; CGP 42446

纯 度

≥98.0%(HPLC)

CAS NO.

118072-93-8

分子式

C⁵H¹⁰N²O⁷P²

分子量

272.09

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

Very slightly soluble

乙醇

≥35mg/mL (0.1M NaOH (aq) )

水

≥25mg/mL

l  生物学信息

生物活性/药理作用

Anhydrous form of a synthetic imidazole third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.

l  包装与存储

包 装

250mg; 1g

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov