产品名称

埃索美拉唑镁(Esomeprazole magnesium)

一般描述

Esomeprazole Magnesium is the magnesium salt of esomeprazole, the S-isomer of omeprazole, with gastric proton pump inhibitor activity.

别 称

magnesium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;Omeprazole Magnesium; Nexium

纯 度

≥99.0%(HPLC)

CAS   NO.

161973-10-0

分子式

C³⁴H³⁶MgN⁶O⁶S²

分子量

713.12

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Esomeprazole Magnesium is the magnesium salt of esomeprazole, the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulphenamide; the active sulphenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H₊/K₊ ATPase), thereby inhibiting its activity and the parietal cell secretion of H₊ ions into the gastric lumen, the final step in gastric acid production. H₊/K₊ ATPase is an integral membrane protein of the gastric parietal cell.

l  包装与存储

包 装

250mg; 1g

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov