产品名称

曲古柳菌素A(Trichostatin A)

一般描述

Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces.

别 称

(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide; TSA; Trichostatin

纯 度

≥98.0%(HPLC)

CAS NO.

58880-19-6

分子式

C¹⁷H²²N²O³

分子量

302.37

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至浅黄色固体

溶解性(25℃)

DMSO

≥20mg/mL

乙醇

Very slightly soluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene tranion and the inhibition of tumor growth. This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals.

l  包装与存储

包 装

5mg; 10mg; 25mg; 100mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov