产品名称

Dorsomorphin(BML-275)

一般描述

Dorsomorphin is a potent, reversible, selective AMPK inhibitor, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type I BMP receptor activity.

别 称

6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;BML 275; Compound C

纯 度

≥99.0%(HPLC)

CAS   NO.

866405-64-3

分子式

C²⁴H²⁵N⁵O

分子量

399.49

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

淡黄色固体

溶解性(25℃)

DMSO

Slightly soluble

乙醇

Slightly soluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type I BMP receptor activity.

l  包装与存储

包 装

5mg; 10mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov