产品名称

Semaxanib

一般描述

Semaxanib(SU5416) is a potent and selective VEGFR (Flk-1/KDR) inhibitor.

别 称

(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one; SU5416; SU5416; SU-5416

纯 度

≥99.0%(HPLC)

CAS   NO.

204005-46-9

分子式

C¹⁵H¹⁴N²O

分子量

238.28

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色或土黄色固体

l  生物学信息

生物活性/药理作用

Semaxanib (SU5416) is a potent and selective VEGFR (Flk-1/KDR) inhibitor with IC50 of   1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Semaxanib is a quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.

l  包装与存储

包 装

5mg; 10mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov