产品名称

S49076

一般描述

S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3.

别 称

3-[[(3Z)-3-[[4-(morpholin-4-ylmethyl)-1H-pyrrol-2-yl]methylidene]-2-oxo-1H-indol-5-yl]methyl]-1,3-thiazolidine-2,4-dione; hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

1265965-22-7

分子式

C²²H²²N⁴O⁴S

分子量

438.502

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色或土黄色固体

l  生物学信息

生物活性/药理作用

S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked   cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked   MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft   models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2   inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth.

l  包装与存储

包 装

5mg; 10mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov