产品名称

盐酸吡格列酮(Pioglitazone Hydrochloride)

一般描述

Pioglitazone Hydrochloride(盐酸吡格列酮) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.

别 称

5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride; AD-4833; U-72107E; 匹格列酮盐酸盐

纯 度

≥99.0%(HPLC)

CAS NO.

112529-15-4

分子式

C¹⁹H²¹ClN²O³S

分子量

392.898

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

~5mg/mL

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates   peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated tranion factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the tranion of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov