产品名称

替米沙坦(Telmisartan)

一般描述

Telmisartan(替米沙坦) is a benzimidazole derivative and a non-peptide angiotensin II receptor  antagonist with antihypertensive property.

别 称

2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid; BIBR 277

纯 度

≥99.0%(HPLC)

CAS NO.

144701-48-4

分子式

C³³H³⁰N⁴O²

分子量

514.629

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或浅黄色固体

溶解性(25℃)

DMSO

≥10mg/mL

乙醇

Very slightly soluble

水

Insolube

l  生物学信息

生物活性/药理作用

Telmisartan is a benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland.   The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure.

l  存储

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov