产品名称

3-吲哚乙酸(Indoleacetic Acid)

一般描述

Indoleacetic acid is a breakdown product of tryptophan metabolism and is often produced by the action of bacteria in the mammalian gut.

别 称

2-(1H-indol-3-yl)acetic acid; Indole-3-acetic acid 3-Indoleacetic acid; Heteroauxin

纯 度

≥98.0%(HPLC)

CAS NO.

87-51-4

分子式

C¹⁰H⁹NO²

分子量

175.187

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或米白色至浅粉色固体

溶解性(25℃)

DMSO

≥25mg/mL

l  生物学信息

生物活性/药理作用

Indoleacetic acid (IAA) is a breakdown product of tryptophan metabolism and is often produced by the action of bacteria in the mammalian gut. Some endogenous production of IAA in mammalian tissues also occurs. It may be produced by the decarboxylation of tryptamine or the oxidative deamination of tryptophan. IAA frequently occurs at low levels in urine and has been found in elevated levels in the urine of patients with phenylketonuria. Using material extracted from human urine, it was discovered by Kogl in 1933 that Indoleacetic acid is also an important  plant hormone. Specifically IAA is a member of the group of phytohormones called auxins. IAA is generally considered to be the most important native auxin. Plant cells synthesize IAA from tryptophan. IAA and some derivatives can be oxidised by horseradish peroxidase (HRP) to cytotoxic species. IAA is only toxic after oxidative decarboxylation; the effect of IAA/HRP is thought to be due in part to the formation of methylene-oxindole, which may conjugate with DNA bases and protein thiols. IAA/HRP could be used as the basis for targeted cancer, a potential new role for plant auxins in cancer therapy.

应 用

Plant Growth Regulators

l  存储

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov