产品名称

盐酸奎宁二水合物(Quinine hydrochloride dihydrate)

一般描述

Quinine hydrochloride dehydrate is an alkaloid derived from the bark of the cinchona tree.

别 称

(8α, 9R)-6’-Methoxycinchonan-9-ol monohydrochloride dihydrate

纯 度

≥98.0%(HPLC)

CAS NO.

6119-47-7

分子式

C²⁰H²⁹ClN²O⁴

分子量

396.91

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

≥40mg/mL

l  生物学信息

生物活性/药理作用

Quinine hydrochloride dihydrate is the sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and tranion via DNA intercalation; and reduction of the excitability of muscle fibers via  alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.

应 用

1. Analgesics, Non-Narcotic

2. Antimalarials

3. Muscle Relaxants, Central

l  存储

存储温度

2-8℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov