产品名称

帕米膦酸二钠(Disodium Pamidronate)

一般描述

Pamidronate disodium is an aminobisphosphonate that inhibits BONE RESORPTION and is used for the treatment of osteolytic lesions.

别 称

disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate; Pamidronic acid disodium salt

纯 度

≥98.0%(HPLC)

CAS NO.

57248-88-1

分子式

C³H⁹NNa²O⁷P²

分子量

279.03

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

Very slightly soluble

乙醇

Insolube

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Pamidronate Disodium is the disodium salt of the synthetic bisphosphonate pamidronate. Although its mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation.

应 用

Pamidronate disodium is an aminobisphosphonate that inhibits BONE RESORPTION and is used for the treatment of osteolytic lesions, bone pain, and severe HYPERCALCEMIA associated with malignancies.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov