产品名称

盐酸多奈哌齐(Donepezil Hydrochloride)

一般描述

Donepezil hydrochloride is an indan and piperidine derivative that acts as a selective and reversible inhibitor of Acetylcholinesterase.

别 称

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one; hydrochloride

纯 度

≥99.0%(HPLC)

CAS NO.

120011-70-3

分子式

C²⁴H³⁰ClNO³

分子量

415.958

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

溶解性(25℃)

DMSO

Slightly soluble

乙醇

Slightly soluble

水

≥10mg/mL

l  生物学信息

生物活性/药理作用

Donepezil Hydrochloride is the hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases.

应 用

1.Nootropic Agents

2.Cholinesterase Inhibitors

l  存储

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov