产品名称

Cefditoren pivoxil

一般描述

Cefditoren Pivoxil is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third generation cephalosporin antibiotic with bactericidal activity.

别 称

ME-1207

纯 度

≥98%(HPLC)

CAS NO.

117467-28-4

分子式

C²⁵H²⁸N⁶O⁷S³

分子量

620.72 g/mol

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

类白色固体

溶解性(25°C)

DMSO

≥50mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Cefditoren Pivoxil is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intestinal esterases during absorption to the microbiologically active cefditoren, an active aminothiazolyl cephalosporin. Cefditoren inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis. Another consequence of beta-lactam exposure results in the loss of lipoteichoic acids from the cell wall. Lipoteichoic acids inhibit murein hydrolase activity and their absence from the cell wall triggers uncontrolled autolytic activity rendering bacterial cells susceptible to osmotic shock. This results in a reduction of cell wall stability and causes cell lysis.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov