产品名称

Riluzole(利鲁唑)

一般描述

Riluzole, a member of the benzothiazole class, is indicated for the treatment of patients with amyotrophic lateral sclerosis (ALS).

别 称

6-(trifluoromethoxy)-1,3-benzothiazol-2-amine; RP-54274; PK 26124;

纯 度

≥98%(HPLC)

CAS NO.

1744-22-5

分子式

C⁸H⁵F³N²OS

分子量

234.2

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

类白色固体

溶解性(25°C)

DMSO

≥40mg/mL

乙醇

≥40mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Riluzole, a member of the benzothiazole class, is indicated for the treatment of patients with amyotrophic lateral sclerosis (ALS). Riluzole extends survival and/or time to tracheostomy. It is also neuroprotective in various in vivo experimental models of neuronal injury involving excitotoxic mechanisms. The etiology and pathogenesis of amyotrophic lateral sclerosis (ALS) are not known, although a number of hypotheses have been advanced. One hypothesis is that motor neurons, made vulnerable through either genetic predisposition or environmental factors, are injured by glutamate. In some cases of familial ALS the enzyme superoxide dismutase has been found to be defective.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov