Dideoxyinosine
商品编号:
TL0916
备注:
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详细介绍
l 基本信息 |
产品名称 | Dideoxyinosine(地达诺辛) |
一般描述 | Didanosine is a nucleoside reverse tranase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). |
别 称 | 9-[(2~{R},5~{S})-5-(hydroxymethyl)oxolan-2-yl]-3~{H}-purin-6-one; Didanosine; 2',3'-Dideoxyinosine |
纯 度 | ≥98%(HPLC) | CAS NO. | 69655-05-6 |
分子式 | C10H12N4O3 | 分子量 | 236.23 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色固体 |
溶解性(25°C) | DMSO | ≥40mg/mL |
乙醇 | Insoluble |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Didanosine is a nucleoside reverse tranase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Didanosine differs from other nucleoside analogues, as it does not have any of the regular bases, instead it has hypoxanthine attached to the sugar ring. Didanosine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse tranase enzyme competitively and act as a chain terminator of DNA synthesis. Didanosine is effective against HIV, and usually used in combination with other antiviral therapy. Switching from long term AZT treatment to didanosine has been shown to be beneficial. Didanosine has weak acid stability and therefore, it is often combined with an antacid. |
l 存储 |
存储温度 | -20℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |