产品名称

Neomycin sulfate(硫酸新霉素)

一般描述

Neomycin Sulfate is the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity.

别 称

Framycetin sulfate; Neomycin B sulphate; Framycin sulfate

纯 度

≥97% (HPLC)

CAS NO.

1405-10-3

分子式

C²³H⁴⁶N⁶O¹³ • 3H²SO⁴

分子量

908.8

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

米黄色固体

溶解性(25°C)

DMSO

Insoluble

乙醇

Insoluble

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Neomycin Sulfate is the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational shift, thereby results in premature termination. This eventually leads to bacterial cell death.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov