产品名称

Lisinopril dehydrate (赖诺普利二水合物)

一般描述

Lisinopril is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

别 称

(S)-1-[N2-(1-carboxy-3-phenylpropyl)-lysyl-proline dehydrate; Lisinopril; MK-521

纯 度

≥99%(HPLC)

CAS NO.

83915-83-7

分子式

C²¹H³¹N³O⁵

分子量

405.49

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

溶解性(25°C)

DMSO

Insoluble

乙醇

Insoluble

水

≥15mg/mL

l  生物学信息

生物活性/药理作用

Lisinopril is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Lisinopril, a synthetic peptide derivative, specifically and competitively inhibits ACE, which results in a decrease in the production of the potent vasoconstrictor angiotensin II and, so, diminished vasopressor activity. In addition, angiotensin II stimulated aldosterone secretion by the adrenal cortex is decreased which results in a decrease in sodium and water retention and an increase in serum potassium.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov