产品名称

Edaravone(依达拉奉)

一般描述

Edaravone is a novel potent free radical scavenger that has been clinically used to reduce the neuronal damage following ischemic stroke.

别 称

5-methyl-2-phenyl-4~{H}-pyrazol-3-one; MCI-186

纯 度

≥98% (HPLC)

CAS NO.

89-25-8

分子式

C¹⁰H¹⁰N²O

分子量

174.2

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

米黄色或浅棕黄色固体

溶解性(25°C)

DMSO

≥30mg/mL

乙醇

≥30mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Edaravone scavenges free hydroxyl radicals and peroxynitrite radicals which are highly associated with neuronal damage/death from many cerebral vascular disorders such as ischemic strokes and degenerative neurological disorders such as ALS. It exerts a neuroprotective and antioxidant effect and delays disease progression by limiting the extent of lipid peroxidation via free radical generation and cell membrane damage from oxidative stress. It reversed the reduction in regional blood flow and cerebral edema in a case of ischemic stroke.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov