产品名称

Triamterene(氨苯蝶啶)

一般描述

Triamterene is a pteridine derivative with potassium-sparing diuretic property.

别 称

6-phenylpteridine-2,4,7-triamine; SKF8542; Dyrenium

纯 度

≥98%(HPLC)

CAS NO.

396-01-0

分子式

C¹²H¹¹N⁷

分子量

253.26

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅绿色固体

溶解性(25°C)

DMSO

≥15mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Triamterene is a pteridine derivative with potassium-sparing diuretic property. Triamterene blocks the sodium-potassium exchange pump (Na-K-ATPase) in the luminal membrane of principal cells in the late distal tubule, cortical collecting tubule and collecting duct in the kidney. This reversible inhibition of the electrogenic sodium transport decreases the lumen negative transepithelial potential difference and thus reduces the driving force for K₊ movement into the tubular lumen resulting in the inhibition of sodium reabsorption in exchange for K₊  and H₊.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov