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Isosorbide 5-mononitrate

商品编号: TL0931
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详细介绍

l  基本信息

产品名称

Isosorbide 5-mononitrate(5-单硝酸异山梨酯)

一般描述

Isosorbide Mononitrate is the mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity.

别 称

Elantan; Monoket, Mononit; Imdur; Corangin

纯 度

≥98%(HPLC)

CAS NO.

16051-77-7

分子式

C6H9NO6

分子量

191.14

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色固体

溶解性(25°C)

DMSO

≥35mg/mL

乙醇

≥35mg/mL

≥35mg/mL

l  生物学信息

生物活性/药理作用

Isosorbide Mononitrate is the mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov