Sulindac sulfone
商品编号：
TL0952
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详细介绍
l 基本信息 |
产品名称 | Sulindac sulfone |
一般描述 | Sulindac sulfone is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. |
别 称 | Sulindac EP Impurity B |
纯 度 | ≥97%(HPLC); 98%(TLC) | CAS NO. | 59864-04-9 |
分子式 | C20H17FO4S | 分子量 | 372.41 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 浅黄色至深黄色固体 |
溶解性(25°C) | DMSO | ≥25mg/mL |
乙醇 | ≥10mg/mL (warmed) |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Sulindac sulfone is a sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor. It has a role as a cyclooxygenase 2 inhibitor, an EC 1.13.11.34 (arachidonate 5 lipoxygenase) inhibitor and an apoptosis inducer. It is a sulfone, a monocarboxylic acid and an organofluorine compound. It derives from a sulindac. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
