产品名称

Pioglitazone(吡格列酮)

一般描述

Pioglitazone is a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, used to treat diabetes A weak activator for full-length hPPARα, but not full-length hPPARδ.

别 称

5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

纯 度

≥98.0%(HPLC)

CAS NO.

111025-46-8

分子式

C¹⁹H²⁰N²O³S

分子量

356.44

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

溶解性(25°C)

DMSO

≥5mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Pioglitazone is an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated tranion factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the tranion of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov