产品名称

Tizanidine HCl(盐酸替扎尼定)

一般描述

Tizanidine HCl is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

别 称

DS 103-282; 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine; hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

64461-82-1

分子式

C⁹H⁹Cl²N⁵S

分子量

290.166

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

溶解性(25°C)

DMSO

≥5mg/ml

乙醇

Insoluble

水

≥15mg/ml

l  生物学信息

生物活性/药理作用

Tizanidine Hydrochloride is the hydrochloride salt form of tizanidine, an imidazoline derivative structurally similar to clonidine and an adrenergic agonist with muscle relaxant property. Tizanidine stimulates alpha-2 adrenergic receptors in the central nervous system, thereby inhibiting presynaptic release of norepinephrine and increasing the inhibitory effect on alpha motor neurons and motor reflexes. Tizanidine exerts some activity at the postsynaptic excitatory amino acid receptors and imidazoline receptors which may contribute to the overall reduction in facilitation of spinal motor neurons. Overall, tizanidine hydrochloride causes muscle relaxation, reduces spasticity and antinociceptive effects.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov