产品名称

Loteprednol etabonate(氯替泼诺)

一般描述

Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.

纯 度

≥98.0%(HPLC)

CAS NO.

82034-46-6

分子式

C²⁴H³¹ClO⁷

分子量

466.955

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

Slightly soluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Loteprednol Etabonate is the etabonate salt form of loteprednol, an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity. Loteprednol etabonate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene . This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Loteprednol etabonate specifically induces phospholipase A2 inhibitory proteins (collectively called lipocortins), which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov