产品名称

Valdecoxib(伐地考昔)

一般描述

Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.

别 称

4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide

纯 度

≥99.0%(HPLC)

CAS NO.

181695-72-7

分子式

C¹⁶H¹⁴N²O³S

分子量

314.359

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

≥5mg/ml

水

Insoluble

l  生物学信息

生物活性/药理作用

Valdecoxib is a sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov