产品名称

Tolterodine tartrate(石酸托特罗定)

一般描述

Tolterodine tartrate is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist.

别 称

PNU-200583E; (2R,3R)-2,3-dihydroxybutanedioic acid; 2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol

纯 度

≥97.0%(HPLC)

CAS NO.

124937-52-6

分子式

C²⁶H³⁷NO⁷

分子量

475.582

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

溶解性(25°C)

DMSO

≥50mg/mL

乙醇

~5mg/mL

水

≥5mg/mL

l  生物学信息

生物活性/药理作用

Tolterodine Tartrate is the tartrate salt form of tolterodine, a benzhydryl compound and a muscarinic receptor antagonist possessing both antimuscarinic and antispasmodic properties. Both tolterodine and its active metabolite, 5-hydroxymethyltolterodine, competitively blocks muscarinic receptors, thereby inhibiting acetylcholine receptor binding. This antagonistic action results in an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, indicating an antimuscarinic action on the lower urinary tract. The 5-hydroxymethyl metabolite appears to contribute significantly to the therapeutic effects.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov