产品名称

Hydroxyzine pamoate(双羟萘酸羟嗪)

一般描述

Hydroxyzine pamoate, a derivative of hydroxyzine, is a histamine H1-receptor antagonist  that has been used as anxiolytic and antihistaminic so that it is probably effective in the treatment of insomnia and withdrawal treatment.

别 称

Hydroxyzine Embonate; Paxisitil; Masmoran; Bobsule; Equipose

纯 度

≥98.0%(HPLC)

CAS NO.

10246-75-0

分子式

C⁴⁴H⁴³ClN²O⁸

分子量

763.27382

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

绿色固体

溶解性(25°C)

DMSO

≥50mg/ml

l  生物学信息

生物活性/药理作用

Hydroxyzine Pamoate is the pamoate salt form of hydroxyzine, a synthetic piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties. Hydroxyzine pamoate blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. In addition, hydroxyzine pamoate crosses the blood-brain barrier and acts on the histamine H1-receptors in the central nervous system.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov