产品名称

Sumatriptan Succinate(琥珀酸舒马曲坦)

一般描述

Sumatriptan Succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.

别 称

GR 43175; butanedioic acid; 1-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-methylmethanesulfonamide

纯 度

≥99.0%(HPLC)

CAS NO.

103628-48-4

分子式

C¹⁸H²⁷N³O⁶S

分子量

413.489

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

米黄色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

Insoluble

水

≥45mg/ml

l  生物学信息

生物活性/药理作用

Sumatriptan Succinate is the succinate salt form of sumatriptan, a member of the triptan class of compounds with anti migraine property. Sumatriptan succinate selectively binds to and activates serotonin 5-HT1 receptors. This results in constriction of meningeal, dural, cerebral or pial blood vessels via stimulation of the 5-HT1B receptors, thereby reducing the vascular pulsation and may provide relief in migraine headaches. Furthermore, agonistic action of this agent through presynaptic stimulation of 5-HT1D and/or 5-HT1F receptors prevents release of vasoactive and pro-inflammatory neuropeptide (calcitonin gene-related peptide), thereby may also relieve migraine headaches. In addition, central inhibition of pain transmission via the inhibition of trigeminal neurons in the brain stems and upper spinal cord mediated by 5-HT1B, 5-HT1D or 5-HT 1F receptors also aides in the alleviation of migraine pain.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov