产品名称

Diphemanil Methylsulfate(甲硫二苯马尼)

一般描述

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).

别 称

4-benzhydrylidene-1,1-dimethylpiperidin-1-ium;methyl sulfate

纯 度

≥98.0%(HPLC)

CAS NO.

62-97-5

分子式

C²¹H²⁷NO⁴S

分子量

389.51

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色结晶

溶解性(25°C)

DMSO

≥15mg/ml

乙醇

Insoluble

水

≥5mg/ml

l  生物学信息

生物活性/药理作用

Diphemanil methylsulfate is the alkene resulting from the formal Wittig olefination of benzophenone and 1,1-dimethyl-4 bromopiperidinium methylsulfate. A quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids, saliva and sweat, It is used topically in the treatment of hyperhidorsis (excessive sweating). It has a role as a muscarinic antagonist, a parasympatholytic and a bronchodilator agent. It is a quaternary ammonium salt and a member of piperidines.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov