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Trazodone hydrochloride

商品编号: TL1132
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详细介绍

l  基本信息

产品名称

Trazodone HCl(盐酸曲唑酮)

一般描述

Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.

别 称

AF-1161, KB-831; 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one; hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

25332-39-2

分子式

C19H23Cl2N5O

分子量

408.327

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色至浅黄色固体

溶解性(25°C)

DMSO

Slightly soluble

乙醇

Insoluble

Insoluble

l  生物学信息

生物活性/药理作用

Trazodone Hydrochloride is the hydrochloride salt form of trazodone, a synthetic triazolopyridine derivative with antidepressant and sedative properties. Based on studies from animal models, trazodone selectively inhibits the re-uptake of serotonin by synaptosomes in the brain, thereby increasing serotonin levels in the synaptic cleft and potentiating serotonin activity. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. The sedative effect of trazodone is likely via alpha-adrenergic and mild histamine H1 blocking actions.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov