产品名称

Fludrocortisone acetate(醋酸氟氢可的松)

一般描述

Fludrocortisone acetate is a synthetic pregnane steroid and a halogenated derivative of cortisol. It is used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency.

别 称

9α-fluorocortisol acetate

纯 度

≥98.0%(HPLC)

CAS NO.

514-36-3

分子式

C²³H³¹FO⁶

分子量

422.493

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥50mg/mL

乙醇

≥5mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Fludrocortisone Acetate is the acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the tranion of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na₊ reabsorption and water retention and K₊ and H₊ secretion in the distal tubules and collecting ducts of the kidney.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov