Imipenem monohydrate
商品编号：
TL1144
备注：
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详细介绍
l 基本信息 |
产品名称 | Imipenem(亚胺培南一水合物) |
一般描述 | Imipenem acts as an inhibitor of AmpC β-lactamase and is an antibiotic useful for the treatment of a number of bacterial infections. |
别 称 | (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; hydrate |
纯 度 | ≥98.5%(HPLC) | CAS NO. | 74431-23-5 |
分子式 | C12H19N3O5S | 分子量 | 317.36 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 类白色至浅黄色固体 |
溶解性(25°C) | DMSO | Slightly soluble |
乙醇 | Insoluble |
水 | ≥50mg/mL |
l 生物学信息 |
生物活性/药理作用 | Imipenem is a broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. Imipenem binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This inactivation results in the weakening of the bacterial cell wall and eventually causes cell lysis. Imipenem has the greatest affinity for PBP 1A, 1B, and 2, and its lethal effect is related to binding to PBP 2 and 1B. This antibiotic is active against a wide range of gram-positive and gram-negative organisms and is stable in the presence of beta-lactamases. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
