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详细介绍
l 基本信息 |
产品名称 | Carmustine(卡莫司汀) |
一般描述 | Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms. |
别 称 | bis-chloroethylnitrosourea; BCNU; 1,3-bis(2-chloroethyl)-1-nitrosourea |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 154-93-8 |
分子式 | C5H9Cl2N3O2 | 分子量 | 214.046 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 浅黄色至黄色无定型固体或油状物 |
l 生物学信息 |
生物活性/药理作用 | Carmustine is an antineoplastic nitrosourea. Carmustine alkylates and cross-s DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
