产品名称

Amikacin disulfate(硫酸阿米卡星)

一般描述

Amikacin sulfate binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.

别  称

BB-K8

纯  度

≥97.0%(HPLC)

CAS NO.

39831-55-5

分子式

C²²H⁴⁷N⁵O²¹S²

分子量

781.752

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外  观

白色粉末

溶解性(25°C)

DMSO

Insoluble

乙醇

Insoluble

水

≥5mg/mL

l  生物学信息

生物活性/药理作用

Amikacin Sulfate is the sulfate salt of amikacin, a broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically in contact with 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov