产品名称

哌立福辛(Perifosine (KRX-0401))

一般描述

Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition.

别 称

(1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate; NSC639966

纯 度

≥98.0%(HPLC)

CAS NO.

157716-52-4

分子式

C²⁵H⁵²NO⁴P

分子量

461.66

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

Insoluble

乙醇

~15mg/mL

水

≥5mg/mL

l  生物学信息

生物活性/药理作用

Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine.

Perifosine is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov