产品名称

丁酸钠(Sodium butyrate)

一般描述

Sodium butyrate(丁酸钠), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).

别 称

sodium;butanoate; Butyric  acid sodium salt

纯 度

≥98.0%(HPLC)

CAS NO.

156-54-7

分子式

C⁴H⁷NaO²

分子量

110.088

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

Insoluble

乙醇

≥20mg/mL

水

≥20mg/mL

l  生物学信息

生物活性/药理作用

Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to tranion-regulatory complexes leads to increased tranional  activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the of other genes and proteins involved in cellular differentiation and apoptotic signaling.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov