Plerixafor (AMD3100)
商品编号：
TS0161
备注：
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详细介绍
l 基本信息 |
产品名称 | 普乐沙福(Plerixafor (AMD3100)) |
一般描述 | Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis. |
别 称 | 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane; JM 3100 |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 110078-46-1 |
分子式 | C28H54N8 | 分子量 | 502.79 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 固体 |
溶解性(25℃) | DMSO | Insoluble |
乙醇 | ≥50mg/mL |
水 | ~3mg/mL(warmed) |
l 生物学信息 |
生物活性/药理作用 | Plerixafor is a bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. |
l 存储 |
存储温度 | -20℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
