产品名称

奥替普拉, 吡噻硫酮(Oltipraz)

一般描述

Oltipraz(奥替普拉) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.

别 称

4-methyl-5-pyrazin-2-yldithiole-3-thione; BRN 0978110, CCRIS 4048, NSC 347901, RP 35972

纯 度

≥98.0%(HPLC)

CAS NO.

64224-21-1

分子式

C⁸H⁶N²S³

分子量

226.34

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

≥35mg/mL(warmed)

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST).

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov