产品名称

BMS-777607

一般描述

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3.

别 称

N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide

纯 度

≥98.0%(HPLC)

CAS NO.

1025720-94-8

分子式

C²⁵H¹⁹ClF²N⁴O⁴

分子量

512.89

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

≥45mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.

应 用

BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov