产品名称

2,5-己酮可可碱(DMXAA (Vadimezan))

一般描述

Vadimezan(2,5-己酮可可碱) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase.

别 称

2-(5,6-dimethyl-9-oxoxanthen-4-yl)acetic acid; ASA404, NSC 640488

纯 度

≥98.0%(HPLC)

CAS NO.

117570-53-3

分子式

C¹⁷H¹⁴O⁴

分子量

282.29

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

≥5mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

DMXAA (Vadimezan) is a small-molecule vascular disrupting agent which targets the blood vessels that nourish tumours. The proposed mechanism of action for ASA404 is directly increasing permeability of the tumor's endothelial cells. Vasoactive mediators such as tumor necrosis factor (TNF) may also be implicated. Increased permeability of tumor cell vasculature may allow increased permeation of anticancer treatments such as cytotoxic drugs, antibodies, drug conjugates and gene therapy.

DMXAA (Vadimezan) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov