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Alvespimycin (17-DMAG) HCl

商品编号: TS0272
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详细介绍

l  基本信息

产品名称

盐酸阿螺旋霉素(Alvespimycin (17-DMAG) HCl)

一般描述

Alvespimycin Hydrochloride(盐酸阿螺旋霉素) is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic  benzoquinone antibiotic geldanamycin.

别 称

[(3R,5S,6R,7S,8E,10S,11S,12E,14E)-21-[2-(dimethylamino)ethylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl]  carbamate;hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

467214-21-7

分子式

C32H48N4O8•HCl

分子量

653.21

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25)

DMSO

≥50mg/mL

乙醇

Insoluble

Insoluble

l  生物学信息

生物活性/药理作用

Alvespimycin Hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and tranion factors involved with cell cycle regulation and signal transduction.

Alvespimycin HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay.

l  存储

存储温度

-20

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov