产品名称

Stattic

一般描述

Stattic, the first nonpeptidic small molecule, has a role as an antineoplastic agent, a STAT3 inhibitor and a radiosensitizing agent.

别 称

6-nitro-1-benzothiophene 1,1-dioxide

纯 度

≥98.0%(HPLC)

CAS NO.

19983-44-9

分子式

C⁸H⁵NO⁴S

分子量

211.19

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

≥40mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Stattic is a member of the class of 1-benzothiophenes that is 1-benzothiophene-1,1-dioxide substituted at position 6 by a nitro group. Used as a radiosensitising agent for esophageal squamous cell carcinoma. It has a role as an antineoplastic agent, a STAT3 inhibitor and a radiosensitizing agent. It is a member of 1-benzothiophenes, a C-nitro compound and a sulfone.

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov