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Fludarabine Phosphate

商品编号: TS0353
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详细介绍

l  基本信息

产品名称

磷酸氟达拉滨(Fludarabine Phosphate)

一般描述

Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity.

别 称

[(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl  dihydrogen phosphate; F-ara-A (NSC 312887) Phosphate

纯 度

≥99.0%(HPLC)

CAS NO.

75607-67-9

分子式

C10H13FN5O7P

分子量

365.21

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25)

DMSO

≥50mg/mL

乙醇

Insoluble

Slightly soluble

l  生物学信息

生物活性/药理作用

Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

l  存储

存储温度

-20

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov