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Daptomycin

商品编号: TS0356
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详细介绍

l  基本信息

产品名称

达托霉素(Daptomycin)

一般描述

Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.

别 称

LY146032

纯 度

≥99.0%(HPLC)

CAS NO.

103060-53-3

分子式

C72H101N17O26

分子量

1620.67

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25)

DMSO

≥50mg/mL(warmed)

乙醇

Insoluble

≥50mg/mL(warmed)

l  生物学信息

生物活性/药理作用

Daptomycin is a semi-synthetic cyclic lipopeptide antibiotic isolated from the bacterium Streptomyces roseosporus with broad-spectrum antibiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux; the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria..

l  存储

存储温度

-20

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov