产品名称

马来酸罗格列酮(Rosiglitazone maleate)

一般描述

Rosiglitazone maleate is a thiazolidinedione that functions as a selective agonist for PPAR GAMMA.

别 称

(Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; BRL49653

纯 度

≥99.0%(HPLC)

CAS NO.

155141-29-0

分子式

C¹⁸H¹⁹N³O³S·C⁴H⁴O⁴

分子量

473.5

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated tranion factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the tranion of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov